Synthetic Biology and Engineered Live Biotherapeutics: Toward Increasing System Complexity

Synthetic Biology and the International Genetically Engineered Machines Competition

Ethical Debates on Synthetic Biology

Background: As an emerging interdisciplinary area of science with a multitude of potential facilities and applications, synthetic biology integrates different disciplines with one another ranging from basic science to engineering. This interdisciplinary branch therefore encompasses sciences that require specific development and ethical approaches. Materials and Methods: Science management princ...

Editorial – Synthetic Biology: Engineering Complexity and Refactoring Cell Capabilities

1 Centre for Synthetic Biology and Innovation, Imperial College London, London, UK, 2 Department of Bioengineering, Imperial College London, London, UK, 3 SYNBIOCHEM, Manchester Institute of Biotechnology, Faculty of Life Sciences, University of Manchester, Manchester, UK, 4 LISBP, INSA, INP, UPS, Université de Toulouse, Toulouse, France, 5 MR792, Ingénierie des Systèmes Biologiques et des Biop...

Asymptomatic Bacteriuria Escherichia coli Are Live Biotherapeutics for UTI

Urinary tract infections (UTI) account for approximately 8 million clinic visits annually with symptoms that include acute pelvic pain, dysuria, and irritative voiding. Empiric UTI management with antimicrobials is complicated by increasing antimicrobial resistance among uropathogens, but live biotherapeutics products (LBPs), such as asymptomatic bacteriuria (ASB) strains of E. coli, offer the ...

Systems approaches for synthetic biology: a pathway toward mammalian design

We review methods of understanding cellular interactions through computation in order to guide the synthetic design of mammalian cells for translational applications, such as regenerative medicine and cancer therapies. In doing so, we argue that the challenges of engineering mammalian cells provide a prime opportunity to leverage advances in computational systems biology. We support this claim ...